Longevity

4/22/06 OCB Core Naturals 1ST Place

Jackie at the April 2006 OCB Core Naturals – 1st Place


“I found the Fountain of Youth,” says Jackie

No kidding! Nobel Prize winning Doctors learned how to turn back the clock! Jackie shares how she was shocked when she experienced these secrets of youth for herself. After 60 days the grey in my hair was gone! My wrinkles around my eyes disappeared! My face was tighter! And my vision even improved – WOW!

My husband looked at me and said, “Honey you look different, so much younger, you really look amazing!” I couldn’t hold back my tears, as the aging process had not been a fun time for me.

Now that I’ve discovered these age defying secrets, I want every middle aged woman out there to “Turn back the Clock” and look their best ever! All you have to do is call me direct… that’s right, no secretaries or staff… If you are serious about wanting to “Turn back your Clock” – then I want to talk to you!

e-mail me at: jackiechristiansen@yahoo.com

or call Jackie at: (970) 406-8928










The Miracle of Resveratrol

resveratrol sourcesIn 2003, The Life Extension Foundation reported on findings that resveratrol (a substance found in red grapes and other plants) extended the life span of certain cells by as much as 70%.

Since their initial report, resveratrol has continued to demonstrate extraordinary potential in prolonging life. In more recent studies—including those at BioMarker Pharmaceuticals, a Life Extension-sponsored research institution—resveratrol demonstrated effects that mimic those of caloric restriction, the best-documented anti-aging strategy to date. In all animals in which it has been tested, caloric restriction improves multiple aspects of age-related decline. Caloric restriction does this, in part, by producing changes in certain gene expressions that are associated with long life and slowing of the aging process.

Resveratrol is also gaining growing recognition for its potential in fighting age-related diseases ranging from dementia to diabetes. For example, the National Institutes of Health is currently sponsoring a clinical trial investigating resveratrol’s ability to fight colon cancer.

Among the life-prolonging benefits of resveratrol supplementation demonstrated in the study were:

increased insulin sensitivity
lower blood sugar
enhanced mitochondrial energy production
improved motor function.

While mice on the non-resveratrol supplemented high-calorie diet developed enlarged, fatty livers, resveratrol supplementation prevented these changes. Similarly, heart disease and evidence of atherosclerosis were seen in mice given the high-calorie diet, but not in those that were also given resveratrol. Resveratrol significantly increased survival, reducing the risk of death from the high-calorie diet by 31%. Together, these findings offer powerful evidence that resveratrol protected the animals from the harmful effects of a high-calorie diet.

Resveratrol’s positive impacts on insulin sensitivity and longevity were apparent after only six months of treatment. Resveratrol also improved the animals’ quality of life, as reflected in their physical abilities. On a test of balance and coordination, the resveratrol-fed mice on the high-calorie diet steadily improved as they aged. The obese resveratrol-supplemented animals experienced all of these benefits without a significant reduction in body weight.

“The data demonstrate that resveratrol can alleviate the negative impacts of a high-calorie diet on overall health and life span,” the Harvard scientists concluded. “The ability of resveratrol to prevent the deleterious effects of excessive caloric intake and modulate known longevity pathways suggests that resveratrol might be a valuable tool in the search for key regulators of energy balance, health, and longevity.”

Mechanisms by Which Resveratrol May Extend Life

Today, scientists around the world are studying resveratrol to determine how it helps fight aging and prolong life span. Current evidence suggests that resveratrol exerts powerful antioxidant effects, boosts energy production, and favorably alters patterns of gene expression.

Oxidative stress is implicated in numerous disease processes and in the aging process itself. Resveratrol demonstrates powerful antioxidant capabilities, with profound implications for human health. Scientists report that resveratrol inhibits the oxidation of dangerous low-density lipoprotein (LDL) and also scavenges harmful hydroxyl radicals. Resveratrol also helps preserve levels of glutathione, one of the body’s most essential antioxidants. According to prominent resveratrol investigator Dr. Milos Sovak, “There is no question that resveratrol is one of the best free-radical scavengers and that it also possesses many effects whose ramifications might affect not only longevity but also general health.”

Resveratrol stimulates energy production in the cellular powerhouses known as the mitochondria. Diminished mitochondrial energy production is associated with reduced longevity. By enhancing the production of life-sustaining energy, resveratrol may help protect against metabolic disease and obesity, thereby improving health and prolonging survival.

Growing evidence indicates that resveratrol influences several genetic pathways, which may underlie its ability to lengthen life. In the recent Harvard study, investigators noted that a high-calorie diet produced numerous changes in gene expression. However, supplemental resveratrol opposed the effects of this high-calorie diet in 144 of 153 significantly altered genetic pathways. Moreover, resveratrol’s effects were dose dependent, with larger amounts yielding greater effects, leading the investigators to suggest that resveratrol may offer “new strategies for treating obesity-related disorders and diseases of aging.” Resveratrol may confer benefits similar to those of caloric restriction by influencing the sirtuin gene known as SIRT2.5,8-10 In the Harvard study, resveratrol helped counteract changes in SIRT2 gene expression induced by a high-calorie diet.

Researchers believe that compounds like resveratrol that either activate or inhibit sirtuin activity may have therapeutic potential for a broad array of human diseases, including cancer, diabetes, heart failure, as well as neurodegenerative conditions such as Alzheimer’s and Huntington’s disease.



What Happens When We Age?

wrinklesHow does your body age? Although our bodies age first at a cellular level, it’s probably the most visible changes that come to mind like gray hair, wrinkles, or your skin that’s lost it’s elasticity. Let’s take a look at the external signs of a series of processes that go on within your cells and bodily systems that together constitute “normal aging”. Scientists are also looking at what we can do to combat these processes and live a long and healthy (cellular) life.

Here are some prominent theories about how time affects your personal biology:

Cellular clock theory – atates that since many human cells do not continue to reproduce indefinitely, aging is a result of cells hitting their programmed reproductive limit.

Immune system decline – Specific immunity cells decline in number and how well they function with age. This leaves the body more vulnerable to life-threatening diseases like cancer.

Cell damage – where parts of cells wear out: An example of this is the shortening of telomeres, the caps on cell chromosomes. Each time a cell reproduces, the chromosome or genetic material loses a bit of the protective cap until the cell can no longer successfully divide to replace dying cells.

Oxidative stress – the theory that free radicals are responsible for damaging DNA and therefore cause of cell death. Though cleanup systems within cells exist, the damage is cumulative over time. Mitochondria, the engines of cell metabolism, are thought to play a central role because of the disproportionate free radicals they produce. This theory has led to the belief that consuming antioxidants in food would help counteract this process.

Good News
The good news is that we can do something about these naturally occurring processes as they contribute to aging. Let’s take a look:

Supplementation with Antioxidants

Anti-oxidants are naturally occurring in many fruits and vegetables and can be taken in concentrated forms through supplementation. Research shows that it requires 38 different antioxidant actives to deal with all 2,200 categories of free radicals in your body. Many scientists are finding that the primary reason for the accelerated aging at the cellular level is because we are experiencing is the one hundred thousand plus new toxins that have been introduced into our environment over the last 50 years. There are 2,200 synthetic chemicals in our environment that didn’t even exist in the last generation. These chemicals oxidize and damage our cells ability to repair and to properly communicate, which may result in accelerated cell death. It is more important more now than ever before to eat right and supplement your healthy diet.

Supplementation with Trace Minerals

Whether due to of food processing or modern farming techniques, foods often lack the nutrients and minerals humans need to survive, so, we have to rely on mineral supplements in order to get essential nutrients. Trace minerals are especially important in this respect since, unlike major minerals such as magnesium, calcium and potassium, these minerals are more difficult to include in a regular diet. Scientists have identified as many as 2,000 biological processes that occur regularly in our bodies, many of which require trace minerals. Most of the foods we eat may now contain up to 75% fewer trace minerals than just 50 years ago. That means that the average American is receiving only about a quarter what our body’s requirements are for trace minerals. Two times Nobel Laureate, Dr. Linus Pauling said that you could trace every disease and every ailment to a mineral deficiency. You’ll want to give your body the proper nutrition in the form of natural vitamins and the 74 essential trace minerals so your body can perform the repairs needed in your body. Trace mineral supplementation is key.


Supplementation with Fucoidon

Fucoidan is a sulfated polysaccharide found mainly in various species of brown seaweed such as kombu, limu moui, bladderwrack, wakame, mozuku, and hijiki as well as the sea cucumber. Limu Moui is the world’s richest source of fucoidan and is found in the pristine waters of the South Pacific Island of Tonga and it’s health benefits are legendary among its people. It has already been cited in hundreds of research studies published the National Library of Medicine’s PubMed database (www.pubmed.gov). These studies suggest that fucoidan may just be the most exciting immune-supporting nutrient ever discovered. Fucoidon has powerful immune system enhancing abilities and regulates the immune system as an immune-modulator. It is also a cell-regenerator and has natural anti-inflammatory properties.

Supplementation for Telomere Support

Cell damage – Each time a cell reproduces, the chromosome or genetic material loses a bit of the protective cap called telomeres. When the cell can no longer divide there is cell death. In humans, telomere length has been correlated with lifespan and is an indicator of a person’s biological age and longevity marker.
Telomere function has been linked to aging – in mice lacking telomerase activity, progressively shortened telomeres are associated with premature aging. It appears that the function of telomeres is to protect the chromosome ends from being recognized as damaged DNA. The great news is that there now is telomere support supplementation available which, according to 2009 Nobel Prize winning scientific research, reverses the aging process.

Glycation – Recommendations
Reduce your consumption of sugar and high glycemic foods and as much as you can, avoid eating foods cooked at high temperatures. Learn which carbs are our best bets to reduce inflammation. If we can keep our carb choices under 55 on the glycemic index we will greatly ameliorate the health and beauty destroying effects of the carbs that are on the upper end of the scale. Fruits and vegetables that score under 55 (on a scale of 0-100) on the index are the best way to satisfy your craving for sweet food. The fiber in fresh fruit helps slow downs the absorption of the sugars. These foods also contain anti-oxidants—which act as natural anti-inflammatories—as well as all kinds of amazing ”phytoceutical” compounds that provide protective, healing therapy to the entire body. Eat some protein at the start of any meal, and try to avoid eating fruit on an empty stomach, to prevent any rapid rise in blood sugar. A rapid rise in our blood sugar from eating sweets and the wrong types of carbs is pro-inflammatory and results in a sharp rise in our insulin levels, after which the insulin drops to below normal levels. This results in the cravings of more carbohydrates, creating a vicious cycle. In addition to disease prevention and skin rejuvenation from wrinkles, you will quickly discover that you are eating less food because low glycemic carbs eliminate food cravings. This can result in the loss of excess weight, which is an added benefit.

Glycation – Supplementation

Resveratrol – contains compounds that may prevent negative effects of AGEs. Resveratrol has the ability to promote optimal mitochondria function and biogenesis as well as contributing to the antioxidant role in protecting cellular DNA and cell membranes. This results in more efficient energy output for the body, and an increased longevity of the cells in the body. The amount of resveratrol that is found in a glass of wine is not enough to yield quantifiable health benefits, this is why people need to supplement with a very potent and quality resveratrol liquid supplement.

Benfotiamine – is a form of vitamin B1, and has been shown strongly to protect against the damage to nerves and blood vessels, caused by glycation. It does this by acting on the triosephosphates caused by glycation, which can damage both blood and nerve cells. Studies have shown that benfotiamine reduces the formation of triosephosphates as well as reducing its effects once it has formed. Benfotiamine has not reported side effects. For all these reasons, Benfotiamine is of particular benefit to diabetics.

Carnosine is a combination of two amino acids, which shields proteins from being attacked by glycotoxins – such as AGEs. A maintenance dose of carnosine is recommended for everyone; for diabetics, a larger dose is highly protective, and has no known side effects.

Summary

As you can see, there are things you can do to slow down the aging process. No one wants to age, especially look or feel old. I’ve only mentioned some of the things you can do to impact the aging process at a cellular level. There are also lifestyle changes, which can impact the rate at which you age – for example, not smoking, eating clean, reducing stress and implementing a regular exercise program.

So be sure to give your body the proper nutrition in the form of natural foods, as well as supplement with the best antioxidants, essential trace minerals and telomere support available. You will be on your way to truly feeling, looking and actually getting younger.